BiForm BIOactive

Mineral-collagen-bioactive glass composite matrix for surgical implantationBiFORM® Bioactive

BiFORM®Bioactive Moldable Bone Graft Matrixis composed of carbonate apatite an organic bone mineral, bioactive glass, and Type I collagen that can be molded to fit the bone defect. It is an osteoconductive, bioactive, porous implant that allows for bony ingrowth across the graft site. The bone graft matrix is slowly resorbed and replaced by new bone tissue during the natural healing process.

Why BiFORM® Bioactive Moldable?

  • A Perfect Trio of Components: 50% Carbonate Apatite anorganic bone mineral,30% 45S5 Bioactive Glass, 20% Type I Collagen
  • Uniform distribution of bioactive glass and mineral particles throughout the matrix, achieved through our proprietary manufacturing process

BiFORM® Bioactive Glass Component

  • 30% is Optimal: Less is more. Bioactive glass is incorporated into BiFORM® Bioactive within asuggested critical range of 5-40% for optimal osteoblast growth and calcium phosphate formation in a composite
  • Ideal Particle Range: A narrow particle size distribution limited to 100-300μm to provide a more controlled rate of ion dissolution & surface reactivity and a more consistent rate of bone bonding & proliferation
  • Exemplary Particle Size (100-300μm): Larger sized particles may not fully resorb. Smaller particles may resorb away quickly and impede the upregulation of osteoprogenitor cells.
Length Width Thickness
- - -
2.5 cc*, 1 Puck
- - -
5.0 cc*, 1 Puck
6.25 cm 2 cm 0.8 cm
10 cc, 1 Strip
12.5 cm 2 cm 0.8 cm
20 cc, 1 Strip
25 cm 2 cm 0.4 cm
40 cc, 1 Strip

Moldable Advantage

  • 2 for 1 versatility—Upon hydration, the strip confirmation can be used in its original shape or optionally molded into alternative shapes to address the unique contours of each defect
  • Combined with either autogenous bonemarrow or autograft with saline
  • Can also be used with autograft as a bone graft extender
  • Puck conformation option is ideal for molding
  • Moldable, flexible, absorbent, resists migration upon irrigation
  • A lengthy 40cc size option unlike any other bioactive moldable bone graft
Almost 2x more absorbent than Vitoss® Bioactive Foam
  • Delivers stem cell rich BMA to fusion site
Natural Mineral Structure Similar to Human Bone Mineral
  • Pores provide pathways for cell migration and attachment to lay down new bone
  • Carbonate apatite is a better osteoconductive material than HA

Data on file at Collagen Matrix, Inc.

Gerhardt, L., Boccaccini, A.R. (2010). Bioactive Glass-Ceramic Scaffolds for Bone Tissue Engineering. Materials, 3, 3867-3910. Retrieved from

Oonishi, H., Kushitani, S., Yasukawa, E., Iwaki, H., Hench, L.L., Wilson, J., Tsuji, E., Sugihara, T. (1997). Particulate Bioglass Compared With Hydroxyapatite as a Bone Graft Substitute. Clinical Orthopedics and Related Research, 334, 316-325, Lippincott-Raven Publishers, Philadelphia, PA.

Schepers, E.J.G., Ducheyne, P. (1997). Bioactive glass particles of narrow size range for the treatment of oral bone defects: a 1-24 month experiment with several materials and particle sizes and size ranges. Journal of Oral Rehabilitation, 24, 171-181.

Lindfors, N. C., Koski, I., Heikkilä, J. T., Mattila, K. and Aho, A. J. (2010), A prospective randomized14‐year follow‐up study of bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors. J. Biomed. Mater. Res., 94B, 157-164. doi:10.1002/jbm.b.31636

Spence, G., Patel, N., Brooks, R., Rushton, N. (in press). Carbonate substituted hydroxyapatite: Resorption by osteoclasts modifies the osteoblastic response. Wiley InterScience. Retrieved from

Kanayama, K., Sriarj, W., Shimokawa, H., Ohya, K., Doi, Y., Shibutani, T. 2011. Osteoclast and osteoblast Activities on Carbonate Apatite Plates in Cell Cultures. J. Biomaterials, 26, 435-436.


BiFORM is a registered trademark of Scandia Biologics Vitoss is a registered trademark of Orthovita, Inc.

Please refer to Instructions for use for description, handling, storage parameters, indications, contraindications, warnings, precautions, and other important information. A surgeon must always rely on his or her own professional clinical judgment when deciding whether to use a particular product when treating a particular patient.

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