Amnioworks

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BETTER OCULAR HEALING IN A REGENERATIVE WAY

What is AmnioWorks™?

AmnioWorks™ is derived from human amniotic membrane recovered following a live birth from volunteer donors. Amnion tissue is known to be an immune-privileged tissue containing growth factors and cytokines that impact tissue repair and regeneration.

AmnioWorks™ technology produces decellularized biological tissue with virtually no structural disruption, thus providing an optimal replacement for the damaged extracellular matrix, allowing the patient’s living, native cells to populate and integrate ultimately achieving the goals of soft tissue healing and regeneration.

Why AmnioWorks™?

  • Amniotic membrane has been shown to provide substantial benefit in treating certain types of conjunctival and corneal disease
  • Air-dried; not freeze-dried (air-dried is gentler on tissue)
  • High-quality internal packaging offers a 5-year shelf life
  • No antibiotics are used in the sterilization process
  • Store at room temperatures; no need for freezer
  • Can place a disc on the ocular surface in either direction
  • Adheres to the ocular surface, hydrates rapidly
  • Sterilized with low-dose, low-temperature gamma radiation to achieve sterility assurance level (SAL) of 10-6

What is amniotic membrane?

The amniotic membrane is a placental tissue that supports the development of the fetus during pregnancy. It is composed of extracellular matrix(ECM) components such as collagen, fibronectin, and laminin, and contains many different growth factors and cytokines.

The amniotic membrane is composed of 2 distinct layers that surround the embryo: the amnion that lines the inner surface of the amniotic sac interfacing with the fetus, and the chorion that is the outer layer in contact with maternal tissue.

Park C, Y, Kohanim S, Zhu L, Gehlbach P, L, Chuck R, S: Immunosuppressive Property of Dried Human Amniotic Membrane. Ophthalmic Res 2009;41:112-113. doi: 10.1159/000187629.

Mamede AC, Carvalho MJ, Abrantes AM, et al. Amniotic membrane: from structure and functions to clinical applications. Cell Tissue Res.2012;349:447–458.

Toda A, Okabe M, Yoshida T, et al. The potential of amniotic membrane/amnion-derived cells for regeneration of various tissues. JPharmacol Sci. 2007;105:215–228.

What does it treat?

  • Corneal erosions, defects and ulcers
  • Acute thermal/chemical burns
  • Persistent epithelial defects
  • Keratitis/Post-infectious Keratitis
  • Corneal/pterygium surgical procedures
  • Recalcitrant corneal inflammation
  • Keratoconjunctivitis/Sicca
  • Persistent band/bullous Keratopathy
  • Ocular surface cell damage
  • Foreign body removal
  • Severe dry eye disease
AmnioWorks™ is available in multiple size designed to closely optimize membrane defects

(a) Before Amniotic Membrane Patching (AMP). Entire corneal epithelia and a large area of conjunctival epithelia were denuded.

(b) One month after. Corneal and conjunctival surface is smooth and quiet.

(c) Amniotic membrane transplantation (AMT) in infectious corneal ulceration (see area marked with stars):

Is AminoWorks™ safe?

AmnioWorks™ is derived from human amniotic membrane that is harvested upon scheduled cesarean section from volunteer donors who undergo rigorous screening for viral and infectious diseases.

AmnioWorks™ is a safe, effective treatment provided by Tissue Regenix, approved by American Association of Tissue Banks (AATB), and regulated by the FDA.

AmnioWorks™ amnion patch grafts may be rehydrated according to the clinician’s preference and may be used as membrane for applications in accordance with the physician’s well-informed medical judgment.

  • Low immunogenicity
  • Protective covering
  • Non-steroidal, natural
  • Scaffold for tissue reconstruction

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